University of Wisconsin–Madison

Welcome to the Mosher Lab

Our lab focuses on the repercussions of interleukin-mediated eosinophil activation. Eosinophils are inappropriately activated in asthma and other eosinophilia-related conditions. Eosinophils undergo a dramatic shape change post-stimulation, with the nucleus moving to one pole (the nucleopod; Han and Mosher, 2014) and the granule proteins to the other. We are most interested in investigating the ways in which nucleopod formation is regulated, and analyzing the contents of granule proteins.

Recent Publications

Barretto KT, Swanson CM, Nguyen CLAnnis DS, Esnault SJ, Mosher DFJohansson MW. Control of cytokine-driven eosinophil migratory behavior by TGF-beta-induced protein (TGFBI) and periostin. PLoS One. 2018 Jul 26;13(7):e0201320.

Bortnov VAnnis DS, Fogerty FJ, Barretto KT, Turton KBMosher DFMyeloid-derived growth factor is a resident endoplasmic reticulum protein. J Biol Chem. 2018 Aug 24;293(34):13166-13175.