Welcome to the Mosher Lab
Our lab focuses on the repercussions of interleukin-mediated eosinophil activation. Eosinophils are inappropriately activated in asthma and other eosinophilia-related conditions. Eosinophils undergo a dramatic shape change post-stimulation, with the nucleus moving to one pole (the nucleopod; Han and Mosher, 2014) and the granule proteins to the other. We are most interested in investigating the ways in which nucleopod formation is regulated, and analyzing the contents of granule proteins.