Welcome to the Mosher Lab
Our lab focuses on the repercussions of interleukin-mediated eosinophil activation. Eosinophils are inappropriately activated in asthma and other eosinophilia-related conditions. Eosinophils undergo a dramatic shape change post-stimulation, with the nucleus moving to one pole (the nucleopod; Han and Mosher, 2014) and the granule proteins to the other. We are most interested in investigating the ways in which nucleopod formation is regulated, and analyzing the contents of granule proteins.
Barretto KT, Swanson CM, Nguyen CL, Annis DS, Esnault SJ, Mosher DF, Johansson MW. Control of cytokine-driven eosinophil migratory behavior by TGF-beta-induced protein (TGFBI) and periostin. PLoS One. 2018 Jul 26;13(7):e0201320.
Bortnov V, Annis DS, Fogerty FJ, Barretto KT, Turton KB, Mosher DF. Myeloid-derived growth factor is a resident endoplasmic reticulum protein. J Biol Chem. 2018 Aug 24;293(34):13166-13175.